all Publications

Qu, Y., Edwards, K., Li, M., Williams, M., Liu, Y., Tsai, P.Y., Cheng, C., Blum, J.E., Acor, N., Oshoe, T., Walter, C., Thirumalaikumar, V., Thalacker-Mercer, A.E., Skirycz, A., Barrow, J. Small Molecule Oxybutynin Rescues Proliferative Capacity of Complex III-Defective Muscle Progenitor Cells. (2025) Am J Physiol Cell Physiol. DOI: 10.1152/ajpcell.00141.2025

Xue, S., Benvie, A.M., Blum, J.E., Kolba, N.J., Cosgrove, B.D., Thalacker-Mercer, A., Berry, D.C. Suppressing PDGFRβ Signaling Enhances Myocyte Fusion to Promote Skeletal Muscle Regeneration. (2024) bioRxiv. DOI: 10.1101/2024.10.15.618247

Blum, J.E., Kong, R., Schulman, E.A., Chen, F.M., Upadhyay, R., Romero-Meza, G., Littman, D.R., Fischbach, M.A., Nagashima, K., Sattely, E.S. Discovery and characterization of dietary antigens in oral tolerance. (2024) bioRxiv. DOI: 10.1101/2024.05.26.593976

Nagashima, K., Zhao, A., Atabakhsh, K., Bae, M., Blum, J.E., Weakley, A., Jain, S., Meng, X., Cheng, A.G., Wang, M., Higginbottom, S., Dimas, A., Murugkar, P., Sattely, E.S., Moon, J.J., Balskus, E.P., Fischbach, M.A. Mapping the T cell repertoire to a complex gut bacterial community. (2023) Nature. 621(7977):162-170. DOI: 10.1038/s41586-023-06431-8

Fiddler, J.L., Blum, J.E., Heyden, K.E., Castillo, L.F., Thalacker-Mercer, A.E., Field, M.S. Impairments in SHMT2 expression or cellular folate availability reduce oxidative phosphorylation and pyruvate kinase activity. (2023) Genes & Nutrition. 18(1):5. DOI: 10.1186/s12263-023-00724-3

Blum, J.E., Gheller, B.J., Benvie, A., Field, M.S., Panizza, E., Vacanti, N.M., Berry, D., Thalacker-Mercer, A. Pyruvate Kinase M2 Supports Muscle Progenitor Cell Proliferation but Is Dispensable for Skeletal Muscle Regeneration after Injury. (2021) J Nutr. 151(11):3313-3328. DOI: 10.1093/jn/nxab251

Fiddler, J.L., Xiu, Y., Blum, J.E., Lamarre, S.G., Phinney, W.N., Stabler, S.P., Brosnan, M.E., Brosnan, J.T., Thalacker-Mercer, A.E., Field, M.S. Reduced Shmt2 Expression Impairs Mitochondrial Folate Accumulation and Respiration, and Leads to Uracil Accumulation in Mouse Mitochondrial DNA. (2021) J Nutr. 151(10):2882-2893. DOI: 10.1093/jn/nxab211

Thalacker-Mercer, A., Blum, J. Discovery and application of dietary compounds to optimize human health, a focus on skeletal muscle regeneration. (2021) Curr Opin Biotechnol. 70:131-135. DOI: 10.1016/j.copbio.2021.04.003

Blum, J., Epstein, R., Watts, S., Thalacker-Mercer, A. Importance of Nutrient Availability and Metabolism for Skeletal Muscle Regeneration. (2021) Frontiers in Physiology. 12:696018. DOI: 10.3389/fphys.2021.696018

Chen, H., Blum, J.E., Thalacker-Mercer, A., Gu, Z. Impact of the Whole Genome Duplication Event on PYK Activity and Effects of a PYK1 Mutation on Metabolism in . (2021) Front Mol Biosci. 8:656461. DOI: 10.3389/fmolb.2021.656461

Nichenko, A.S., Sorensen, J.R., Southern, W.M., Qualls, A.E., Schifino, A.G., McFaline-Figueroa, J., Blum, J.E., Tehrani, K.F., Yin, H., Mortensen, L.J., Thalacker-Mercer, A.E., Greising, S.M., Call, J.A. Lifelong Ulk1-Mediated Autophagy Deficiency in Muscle Induces Mitochondrial Dysfunction and Contractile Weakness. (2021) Int J Mol Sci. 22(4). DOI: 10.3390/ijms22041937

Gheller, B.J., Blum, J.E., Lim, E.W., Handzlik, M.K., Hannah Fong, E.H., Ko, A.C., Khanna, S., Gheller, M.E., Bender, E.L., Alexander, M.S., Stover, P.J., Field, M.S., Cosgrove, B.D., Metallo, C.M., Thalacker-Mercer, A.E. Extracellular serine and glycine are required for mouse and human skeletal muscle stem and progenitor cell function. (2021) Molecular Metabolism. 43:101106. DOI: 10.1016/j.molmet.2020.101106

Gheller, B.J., Blum, J.E., Fong, E.H.H., Malysheva, O.V., Cosgrove, B.D., Thalacker-Mercer, A.E. A defined N6-methyladenosine (mA) profile conferred by METTL3 regulates muscle stem cell/myoblast state transitions. (2020) Cell Death Discov. 6(1):95. DOI: 10.1038/s41420-020-00328-5

Ntemiri, A., Ghosh, T.S., Gheller, M.E., Tran, T.T.T., Blum, J.E., Pellanda, P., Vlckova, K., Neto, M.C., Howell, A., Thalacker-Mercer, A., O’Toole, P.W. Whole Blueberry and Isolated Polyphenol-Rich Fractions Modulate Specific Gut Microbes in an In Vitro Colon Model and in a Pilot Study in Human Consumers. (2020) Nutrients. 12(9). DOI: 10.3390/nu12092800

Blum, J.E., Gheller, B.J., Hwang, S., Bender, E., Gheller, M., Thalacker-Mercer, A.E. Consumption of a Blueberry-Enriched Diet by Women for 6 Weeks Alters Determinants of Human Muscle Progenitor Cell Function. (2020) J Nutr. 150(9):2412-2418. DOI: 10.1093/jn/nxaa190

Gheller, B.J., Blum, J., Soueid-Baumgarten, S., Bender, E., Cosgrove, B.D., Thalacker-Mercer, A. Isolation, Culture, Characterization, and Differentiation of Human Muscle Progenitor Cells from the Skeletal Muscle Biopsy Procedure. (2019) JoVE.(150) DOI: 10.3791/59580

Gheller, B.J., Blum, J.E., Merritt, E.K., Cummings, B.P., Thalacker-Mercer, A.E. Peptide YY (PYY) Is Expressed in Human Skeletal Muscle Tissue and Expanding Human Muscle Progenitor Cells. (2019) Frontiers in Physiology. 10:188. DOI: 10.3389/fphys.2019.00188